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sting inhibitor c 176  (TargetMol)


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    TargetMol sting inhibitor c 176
    CD11b was regulated by STING-IRF7 pathway in endometrium. (A) Representative immunohistochemical staining of CD11b in endometrial tissues of WT or STING-deficient mice ( Tmem173 gt ) infected by LPS for 24 h at 400 × magnification (scale bar = 25 μm). (B) The area of CD11b were quantified (n=6). One-way ANOVA test was applied with ** P <0.01 (WT vs. Tmem173 gt in LPS group). (C) STING inhibitor H-151was used to pretreat Ishikawa cell with or without LPS infected for 24 h, then the protein expression of CD11b was detected by Western blotting. (D) Quantification of the amount of CD11b in the four groups (n=5). One-way ANOVA test was applied with * P <0.05 (LPS vs. H-151+LPS group). (E) Quantitative mRNA expression of irf7 in endometrium of mice (n=6). One-way ANOVA test was applied with * P <0.05 (WT vs. Tmem173 gt in LPS group) (F) Representative immunoblots of IRF7 in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (G) Quantification of the amount of IRF7 in the four groups (n=4). One-way ANOVA test was applied with **** P <0.0001(WT vs. Tmem173 gt in LPS group). (H) Representative immunoblots of CEBPB in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (I) Representative immunoblots of IRF7 in STING inhibitor H-151 pretreat Ishikawa cell. (J) Quantification of the amount of IRF7 in the two groups, and t test was applied with * P <0.05 (LPS vs. H-151+LPS group). (K) Quantitative mRNA expression of itgam with IRF7 overexpression in Ishikawa cells, and t test was applied with *** P <0.001 (LPS vs. H-151+LPS group). (L) Representative immunoblots of CD11b with the transfection of IRF7 in Ishikawa cells. (M) Quantification of the amount of CD11b in the two groups, and t test was applied with * P <0.05 (LPS vs. IRF7+LPS group). (N) Detection of CD11b expression by flow cytometry in mice bone marrow neutrophils stimulated with STING inhibitor <t>C-176.</t> (O) Quantification of CD11b expression on Ly6G + CD45 + cells in mice bone marrow neutrophils stimulated with STING inhibitor C-176., and t test was applied with **** P <0.0001. Independent experiments are repeated at least three times.
    Sting Inhibitor C 176, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sting inhibitor c 176/product/TargetMol
    Average 94 stars, based on 11 article reviews
    sting inhibitor c 176 - by Bioz Stars, 2026-04
    94/100 stars

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    1) Product Images from "Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation"

    Article Title: Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

    Journal: Frontiers in Immunology

    doi: 10.3389/fimmu.2025.1671848

    CD11b was regulated by STING-IRF7 pathway in endometrium. (A) Representative immunohistochemical staining of CD11b in endometrial tissues of WT or STING-deficient mice ( Tmem173 gt ) infected by LPS for 24 h at 400 × magnification (scale bar = 25 μm). (B) The area of CD11b were quantified (n=6). One-way ANOVA test was applied with ** P <0.01 (WT vs. Tmem173 gt in LPS group). (C) STING inhibitor H-151was used to pretreat Ishikawa cell with or without LPS infected for 24 h, then the protein expression of CD11b was detected by Western blotting. (D) Quantification of the amount of CD11b in the four groups (n=5). One-way ANOVA test was applied with * P <0.05 (LPS vs. H-151+LPS group). (E) Quantitative mRNA expression of irf7 in endometrium of mice (n=6). One-way ANOVA test was applied with * P <0.05 (WT vs. Tmem173 gt in LPS group) (F) Representative immunoblots of IRF7 in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (G) Quantification of the amount of IRF7 in the four groups (n=4). One-way ANOVA test was applied with **** P <0.0001(WT vs. Tmem173 gt in LPS group). (H) Representative immunoblots of CEBPB in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (I) Representative immunoblots of IRF7 in STING inhibitor H-151 pretreat Ishikawa cell. (J) Quantification of the amount of IRF7 in the two groups, and t test was applied with * P <0.05 (LPS vs. H-151+LPS group). (K) Quantitative mRNA expression of itgam with IRF7 overexpression in Ishikawa cells, and t test was applied with *** P <0.001 (LPS vs. H-151+LPS group). (L) Representative immunoblots of CD11b with the transfection of IRF7 in Ishikawa cells. (M) Quantification of the amount of CD11b in the two groups, and t test was applied with * P <0.05 (LPS vs. IRF7+LPS group). (N) Detection of CD11b expression by flow cytometry in mice bone marrow neutrophils stimulated with STING inhibitor C-176. (O) Quantification of CD11b expression on Ly6G + CD45 + cells in mice bone marrow neutrophils stimulated with STING inhibitor C-176., and t test was applied with **** P <0.0001. Independent experiments are repeated at least three times.
    Figure Legend Snippet: CD11b was regulated by STING-IRF7 pathway in endometrium. (A) Representative immunohistochemical staining of CD11b in endometrial tissues of WT or STING-deficient mice ( Tmem173 gt ) infected by LPS for 24 h at 400 × magnification (scale bar = 25 μm). (B) The area of CD11b were quantified (n=6). One-way ANOVA test was applied with ** P <0.01 (WT vs. Tmem173 gt in LPS group). (C) STING inhibitor H-151was used to pretreat Ishikawa cell with or without LPS infected for 24 h, then the protein expression of CD11b was detected by Western blotting. (D) Quantification of the amount of CD11b in the four groups (n=5). One-way ANOVA test was applied with * P <0.05 (LPS vs. H-151+LPS group). (E) Quantitative mRNA expression of irf7 in endometrium of mice (n=6). One-way ANOVA test was applied with * P <0.05 (WT vs. Tmem173 gt in LPS group) (F) Representative immunoblots of IRF7 in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (G) Quantification of the amount of IRF7 in the four groups (n=4). One-way ANOVA test was applied with **** P <0.0001(WT vs. Tmem173 gt in LPS group). (H) Representative immunoblots of CEBPB in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (I) Representative immunoblots of IRF7 in STING inhibitor H-151 pretreat Ishikawa cell. (J) Quantification of the amount of IRF7 in the two groups, and t test was applied with * P <0.05 (LPS vs. H-151+LPS group). (K) Quantitative mRNA expression of itgam with IRF7 overexpression in Ishikawa cells, and t test was applied with *** P <0.001 (LPS vs. H-151+LPS group). (L) Representative immunoblots of CD11b with the transfection of IRF7 in Ishikawa cells. (M) Quantification of the amount of CD11b in the two groups, and t test was applied with * P <0.05 (LPS vs. IRF7+LPS group). (N) Detection of CD11b expression by flow cytometry in mice bone marrow neutrophils stimulated with STING inhibitor C-176. (O) Quantification of CD11b expression on Ly6G + CD45 + cells in mice bone marrow neutrophils stimulated with STING inhibitor C-176., and t test was applied with **** P <0.0001. Independent experiments are repeated at least three times.

    Techniques Used: Immunohistochemical staining, Staining, Infection, Expressing, Western Blot, Over Expression, Transfection, Flow Cytometry



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    CD11b was regulated by STING-IRF7 pathway in endometrium. (A) Representative immunohistochemical staining of CD11b in endometrial tissues of WT or STING-deficient mice ( Tmem173 gt ) infected by LPS for 24 h at 400 × magnification (scale bar = 25 μm). (B) The area of CD11b were quantified (n=6). One-way ANOVA test was applied with ** P <0.01 (WT vs. Tmem173 gt in LPS group). (C) STING inhibitor H-151was used to pretreat Ishikawa cell with or without LPS infected for 24 h, then the protein expression of CD11b was detected by Western blotting. (D) Quantification of the amount of CD11b in the four groups (n=5). One-way ANOVA test was applied with * P <0.05 (LPS vs. H-151+LPS group). (E) Quantitative mRNA expression of irf7 in endometrium of mice (n=6). One-way ANOVA test was applied with * P <0.05 (WT vs. Tmem173 gt in LPS group) (F) Representative immunoblots of IRF7 in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (G) Quantification of the amount of IRF7 in the four groups (n=4). One-way ANOVA test was applied with **** P <0.0001(WT vs. Tmem173 gt in LPS group). (H) Representative immunoblots of CEBPB in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (I) Representative immunoblots of IRF7 in STING inhibitor H-151 pretreat Ishikawa cell. (J) Quantification of the amount of IRF7 in the two groups, and t test was applied with * P <0.05 (LPS vs. H-151+LPS group). (K) Quantitative mRNA expression of itgam with IRF7 overexpression in Ishikawa cells, and t test was applied with *** P <0.001 (LPS vs. H-151+LPS group). (L) Representative immunoblots of CD11b with the transfection of IRF7 in Ishikawa cells. (M) Quantification of the amount of CD11b in the two groups, and t test was applied with * P <0.05 (LPS vs. IRF7+LPS group). (N) Detection of CD11b expression by flow cytometry in mice bone marrow neutrophils stimulated with STING inhibitor <t>C-176.</t> (O) Quantification of CD11b expression on Ly6G + CD45 + cells in mice bone marrow neutrophils stimulated with STING inhibitor C-176., and t test was applied with **** P <0.0001. Independent experiments are repeated at least three times.
    Sting Inhibitor C 176, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    sting inhibitor c 176 - by Bioz Stars, 2026-04
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    		  Buy from Supplier
    sting inhibitor c176  (MedChemExpress)
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    MedChemExpress sting inhibitor c176
    CD11b was regulated by STING-IRF7 pathway in endometrium. (A) Representative immunohistochemical staining of CD11b in endometrial tissues of WT or STING-deficient mice ( Tmem173 gt ) infected by LPS for 24 h at 400 × magnification (scale bar = 25 μm). (B) The area of CD11b were quantified (n=6). One-way ANOVA test was applied with ** P <0.01 (WT vs. Tmem173 gt in LPS group). (C) STING inhibitor H-151was used to pretreat Ishikawa cell with or without LPS infected for 24 h, then the protein expression of CD11b was detected by Western blotting. (D) Quantification of the amount of CD11b in the four groups (n=5). One-way ANOVA test was applied with * P <0.05 (LPS vs. H-151+LPS group). (E) Quantitative mRNA expression of irf7 in endometrium of mice (n=6). One-way ANOVA test was applied with * P <0.05 (WT vs. Tmem173 gt in LPS group) (F) Representative immunoblots of IRF7 in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (G) Quantification of the amount of IRF7 in the four groups (n=4). One-way ANOVA test was applied with **** P <0.0001(WT vs. Tmem173 gt in LPS group). (H) Representative immunoblots of CEBPB in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (I) Representative immunoblots of IRF7 in STING inhibitor H-151 pretreat Ishikawa cell. (J) Quantification of the amount of IRF7 in the two groups, and t test was applied with * P <0.05 (LPS vs. H-151+LPS group). (K) Quantitative mRNA expression of itgam with IRF7 overexpression in Ishikawa cells, and t test was applied with *** P <0.001 (LPS vs. H-151+LPS group). (L) Representative immunoblots of CD11b with the transfection of IRF7 in Ishikawa cells. (M) Quantification of the amount of CD11b in the two groups, and t test was applied with * P <0.05 (LPS vs. IRF7+LPS group). (N) Detection of CD11b expression by flow cytometry in mice bone marrow neutrophils stimulated with STING inhibitor <t>C-176.</t> (O) Quantification of CD11b expression on Ly6G + CD45 + cells in mice bone marrow neutrophils stimulated with STING inhibitor C-176., and t test was applied with **** P <0.0001. Independent experiments are repeated at least three times.
    Sting Inhibitor C176, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sting inhibitor c176/product/MedChemExpress
    Average 96 stars, based on 1 article reviews
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    CD11b was regulated by STING-IRF7 pathway in endometrium. (A) Representative immunohistochemical staining of CD11b in endometrial tissues of WT or STING-deficient mice ( Tmem173 gt ) infected by LPS for 24 h at 400 × magnification (scale bar = 25 μm). (B) The area of CD11b were quantified (n=6). One-way ANOVA test was applied with ** P <0.01 (WT vs. Tmem173 gt in LPS group). (C) STING inhibitor H-151was used to pretreat Ishikawa cell with or without LPS infected for 24 h, then the protein expression of CD11b was detected by Western blotting. (D) Quantification of the amount of CD11b in the four groups (n=5). One-way ANOVA test was applied with * P <0.05 (LPS vs. H-151+LPS group). (E) Quantitative mRNA expression of irf7 in endometrium of mice (n=6). One-way ANOVA test was applied with * P <0.05 (WT vs. Tmem173 gt in LPS group) (F) Representative immunoblots of IRF7 in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (G) Quantification of the amount of IRF7 in the four groups (n=4). One-way ANOVA test was applied with **** P <0.0001(WT vs. Tmem173 gt in LPS group). (H) Representative immunoblots of CEBPB in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (I) Representative immunoblots of IRF7 in STING inhibitor H-151 pretreat Ishikawa cell. (J) Quantification of the amount of IRF7 in the two groups, and t test was applied with * P <0.05 (LPS vs. H-151+LPS group). (K) Quantitative mRNA expression of itgam with IRF7 overexpression in Ishikawa cells, and t test was applied with *** P <0.001 (LPS vs. H-151+LPS group). (L) Representative immunoblots of CD11b with the transfection of IRF7 in Ishikawa cells. (M) Quantification of the amount of CD11b in the two groups, and t test was applied with * P <0.05 (LPS vs. IRF7+LPS group). (N) Detection of CD11b expression by flow cytometry in mice bone marrow neutrophils stimulated with STING inhibitor C-176. (O) Quantification of CD11b expression on Ly6G + CD45 + cells in mice bone marrow neutrophils stimulated with STING inhibitor C-176., and t test was applied with **** P <0.0001. Independent experiments are repeated at least three times.

    Journal: Frontiers in Immunology

    Article Title: Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

    doi: 10.3389/fimmu.2025.1671848

    Figure Lengend Snippet: CD11b was regulated by STING-IRF7 pathway in endometrium. (A) Representative immunohistochemical staining of CD11b in endometrial tissues of WT or STING-deficient mice ( Tmem173 gt ) infected by LPS for 24 h at 400 × magnification (scale bar = 25 μm). (B) The area of CD11b were quantified (n=6). One-way ANOVA test was applied with ** P <0.01 (WT vs. Tmem173 gt in LPS group). (C) STING inhibitor H-151was used to pretreat Ishikawa cell with or without LPS infected for 24 h, then the protein expression of CD11b was detected by Western blotting. (D) Quantification of the amount of CD11b in the four groups (n=5). One-way ANOVA test was applied with * P <0.05 (LPS vs. H-151+LPS group). (E) Quantitative mRNA expression of irf7 in endometrium of mice (n=6). One-way ANOVA test was applied with * P <0.05 (WT vs. Tmem173 gt in LPS group) (F) Representative immunoblots of IRF7 in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (G) Quantification of the amount of IRF7 in the four groups (n=4). One-way ANOVA test was applied with **** P <0.0001(WT vs. Tmem173 gt in LPS group). (H) Representative immunoblots of CEBPB in LPS-stimulated STING-deficient mice ( Tmem173 gt ) endometrium tissues, compared with WT-LPS stimulated mice. (I) Representative immunoblots of IRF7 in STING inhibitor H-151 pretreat Ishikawa cell. (J) Quantification of the amount of IRF7 in the two groups, and t test was applied with * P <0.05 (LPS vs. H-151+LPS group). (K) Quantitative mRNA expression of itgam with IRF7 overexpression in Ishikawa cells, and t test was applied with *** P <0.001 (LPS vs. H-151+LPS group). (L) Representative immunoblots of CD11b with the transfection of IRF7 in Ishikawa cells. (M) Quantification of the amount of CD11b in the two groups, and t test was applied with * P <0.05 (LPS vs. IRF7+LPS group). (N) Detection of CD11b expression by flow cytometry in mice bone marrow neutrophils stimulated with STING inhibitor C-176. (O) Quantification of CD11b expression on Ly6G + CD45 + cells in mice bone marrow neutrophils stimulated with STING inhibitor C-176., and t test was applied with **** P <0.0001. Independent experiments are repeated at least three times.

    Article Snippet: Following incubation with the STING agonist cGAMP (20 mM, T10065, targetMol, China) and STING inhibitor C-176 (1 μM, T5154, targetMol, China) or H-151 (1 μM, HY-112693, MedChem Express, USA) or vehicle (saline containing 0.5% DMSO) for 30 min after incubation with 1μg/mL LPS at 37°C for 2.5h.

    Techniques: Immunohistochemical staining, Staining, Infection, Expressing, Western Blot, Over Expression, Transfection, Flow Cytometry